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Researchers developed AOD-9604 to investigate specific metabolic signaling pathways associated with growth hormone biology while excluding many of the broader physiological effects traditionally associated with full-length growth hormone

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However, the requirement for HSL phosphorylation has recently been challenged as studies by the Granneman group elegantly show that direct activation of PNPLA2 in the absence of PKA stimulation is sensitive to HSL inhibition, suggesting that PNPLA2-mediated generation of DAG is sufficient to promote HSL activity (49)