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123 In addition, the common pathogenic bacteria of COPD, nontypeable Haemophilus influenzae , contains cytoplasmic proteins that up-regulate human MUC5AC mucin transcription via a positive p38MAPK pathway and a negative phosphoinositide 3-kinase-Akt pathway

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Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease