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Similar content being viewed by others Introduction The presynaptic release of neurotransmitters is a prelude to their diffusion across the synaptic cleft and subsequent activation of postsynaptic ionotropic receptors, which are responsible for fast chemical neurotransmission

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This approach increased the effective drug concentrations in the brain, improved cognitive performance, reduced Aβ deposition, attenuated neuroinflammation and oxidative stress, inhibited aberrant activation of astrocytes and microglia, and rescued neuronal apoptosis in AD mouse models [52]