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Additionally, in lung cancer cells and osteosarcoma cells, LDHA phosphorylation at serine 196 by ULK1 promotes lactate generation, which subsequently induces PIK3C3 and Vps34 lactylation at lysine 356 and lysine 781, respectively

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Furthermore, the ratio of γH2AX + cells was elevated by pefloxacin, which was reversed by co-treatment with dexamethasone (Figures 6E, F), consistent with the in vivo data (Figures 4F, G)