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10.2174/1567205017666201203123046 130 ZhangH.HeS.SpeeC.IshikawaK.HintonD

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In the landmark study that introduced it, published in Cell Metabolism (Lee et al., 2015), researchers showed that MOTS-c regulates insulin sensitivity and metabolic homeostasis through the AMPK pathway, and that treatment prevented diet-induced obesity and insulin resistance in animal models