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In the mPFC and hippocampus of mice exposed to chronic social defeat stress, the expression of astrocytic connexins is significantly reduced, and lower neuronal activity is observed (Huang et al., 2019

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Indeed, vitamin therapy (folic acid, pyridoxine plus cyanocobalamin) reportedly retards the progression of carotid plaques in patients with plasma homocysteine above and below 14 μmol/L (Hackam et al, 2000)