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TLRs are a family of innate immune recognition receptors that activate myeloid differentiation factor 88 and NF-κB (Yuan et al., 2023), NF-κB is a transcription factor that plays a key role in cellular inflammatory and immune responses (Yuan J

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In addition, quercetin reduces oxidative damage to epithelial cells in lung inflammation [127] and inhibits MUC5AC expression in human airway epithelial cells, suggesting its potential in addressing mucus hypersecretion in COPD [128]