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In addition, it has been proposed that it has roles in atherogenesis and endothelial dysfunction, ocular disorders, fibrosis, iatrogenic diseases, bone regeneration, and increased risk of cardiovascular diseases, among others [242]

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Consequently its metabolites such as carbon monoxide (CO), biliverdin (BV) and bilirubin (BR) could become parts of a therapeutic strategy for treatment of various inflammatory illnesses Key words Biliverdin, bilirubin, antioxidant, anti-inflammatory, cytoprotection