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Growth hormone was identified by Evans and Long in 1921 as a pituitary-derived factor promoting growth in rodents, and the complete biological characterisation of human GH biology spans more than a century of endocrinology research establishing GH as the master anabolic hormone of the somatotropic axis , coordinating postnatal growth, body composition regulation, protein synthesis, lipolysis, carbohydrate metabolism, bone metabolism, immune function, and tissue repair through a combination of direct GH receptor-mediated effects and indirect IGF-1-mediated anabolic biology
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After the first injection of normal liposomes or PEGylated liposomes, a second injection of PEGylated liposomes a few days apart resulted in rapid clearance and increased accumulation in the liver and spleen