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10.3389/fphys.2020.00935 Summary Keywords acute kidney injury (AKI), energy metabolic reprogramming, mitochondrial dysfunction, proximal tubular cells (PTC), therapeutic implications Citation Cao M, Zhao X, Xia F, Shi M, Zhao D, Li L and Jiang H (2025) Mitochondrial dysfunction and metabolic reprogramming in acute kidney injury: mechanisms, therapeutic advances, and clinical challenges