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Thus, while these studies were consistent with a reduction in the circulating pool of GDF11 + GDF8 in aged animals, our initial suggestion that systemic levels of GDF11 declined with aging was incorrect, as the GDF11 + GDF8 signal was dominated by GDF8, which has lower potency compared to GDF11 but circulates at substantially higher concentrations

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The activity of lysyl oxidases is highly dependent on cofactor lysyl tyrosylquinone (LTQ) 48