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Another compensatory response to hemolysis and heme is the formation of aggresome-like induced structures (ALIS) on macrophages, p62/SQTM1 aggregates containing ubiquitinated proteins (100, 101)

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Under the premise of ECM degradation, the activation of the STING pathway synergized with immunogenic cell death (ICD) enhances antitumor immune function, thereby promoting the infiltration of effector T cells into tumor tissues