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Ablation of GOT1 in CD8 T cells disrupts the production of serine from glutamate, which is crucial for their proliferation

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GSH is known to cleave disulfide and diselenide bonds by binding to one cleaved thiol/selenol, forming another disulfide or sulfide-selenide linkage, liberating the other half of disulfide/diselenide as a thiol/selenol, thus being an efficient reducing agent