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Although a protective effect of NGF was observed in embryonic neuronal explants treated with paclitaxel (Konings et al., 1994), these findings were not replicated in dissociated neurons derived from adult rats (Pittman et al., 2016), thus there might be a contribution of development in the protective effects of NGF on neuronal morphology

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Together with an increase in the average life span, especially in developed countries, the frequency of dementia has dramatically increased