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Subsequent reperfusion triggers an abrupt overproduction of ROS, including hydrogen peroxide, superoxide anion, hydroxyl radical, singlet oxygen, hypochlorous acid, and nitric oxide 33 , amplifying oxidative stress and aggravating tissue injury

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PLoS One (2012) 7(8):e44136.10.1371/journal.pone.0044136 241 CuneoRCHickmanPEWallaceJDTehBTWardGVeldhuisJDet alAltered endogenous growth hormone secretory kinetics and diurnal GH-binding protein profiles in adults with chronic liver disease