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FIGURE 9 The core of this toxicity mechanism lies in the depletion of the labile Fe 2+ pool (Figure 5B)—without altering total cellular iron (Figure 5A)—which triggers a compensatory iron-starvation response (IREB2↑, TfR1↑, Ferritin↓

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Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina