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Studies have shown that targeting the autocrine cytokine IL-21 in the TFH cells of mouse models of SLE can help suppress the proliferation and development of TFH and Th17 cells, providing a treatment for SLE (142)

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Thus, key mechanistic steps in the cellular signaling cascade induced in the liver after APAP overdose first discovered in animal models have been corroborated in human hepatocytes and also indirectly by circulating biomarkers from human patients