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Of these, glutathione conjugation, catalyzed by glutathione S-transferases (GSTs), serves as a key defense mechanism against electrophilic xenobiotics (51)

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An animal model using rats given MPH twice daily at a dose of 5 mg/kg showed that the GSH/GSSG ratio in the brain and heart increased (with a decrease in GSSG but no increase in GSH), but in the heart it caused interstitial edema, vascular congestion, and the presence of fibrin-like material in the interstitial space

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