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Ethics approval All animal studies were approved by the local animal care authorities, Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen (LANUV), NRW, Germany (AZ: 2018.A030 and 2016.A212) and conformed to the guidelines from Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes