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Jerjes et al., 2006) in ME/CFS, indicating that HPA axis hypofunction represents an important neuroendocrine feature of the disorder

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Levothyroxine is dosed roughly by body weight (about 1.6 mcg/kg for full replacement), so a patient who loses 15 to 20 percent of body weight on tirzepatide often becomes over-replaced, with symptoms like palpitations, anxiety, and heat intolerance that get misread as drug side effects