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Similar to IL-1β, TNF-α might boost the expression of AMPA receptors, facilitating the entry of calcium ions into neurons, while concurrently diminishing the expression of GABA receptors, thereby weakening the potency of inhibitory synapses

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For peptides where a sharp pharmacokinetic peak is desirable (such as HCG for its LH-mimetic effect), IM may be the preferred research route [4]