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Long-term levodopa treatment, while effective in alleviating motor symptoms, has been associated with increased oxidative stress and the generation of toxic metabolites, which can accelerate the loss of dopaminergic neurons

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[DOI] [PMC free article] [PubMed] [Google Scholar] 135.Wei H., Huang H., He H., Xiao Y., Chun L., Jin Z., Li H., Zheng L., Zhao J., Qin Z