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1 Introduction Diabetes mellitus (DM) is a heterogeneous group of disorders of glucose metabolism dysfunction ( Hyperglycemia is widely considered the primary etiological factor in the development of DKD, as it encourages metabolic and hemodynamic changes in the kidney, causing alterations in renal component structure and function such as glomerulosclerosis, tubulointerstitial inflammation, and fibrosis, which contribute to a decrease in glomerular filtration rate (GFR), ever-increasing albuminuria, and ultimately renal failure ( Long non-coding RNAs (LncRNAs), which are linear transcripts longer than 200 nucleotides that lack protein-translation potential, are of low abundance and stability making up the majority of non-coding RNAs (ncRNAs) in the genome ( Among them, lncRNA H19, the first imprinted and maternally expressed gene to be discovered in eukaryotes ( Figure 1 )