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2.3 Other non-canonical bridging regulatory factors Other non-canonical autophagy regulatory proteins like Sestrin2 (Kimura et al., 2015) also participate in the regulation of Nrf2 and mTOR via direct or indirect interactions, providing novel targets for pondering the connection between autophagy and the Nrf2 antioxidant pathway

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The fibrosis resulting from this process reduces the organ’s original functions due to the replacement of the original tissue with fibrous tissue, mostly composed of collagen, which can thus reduce liver function and cause liver failure [182,183,184,185]