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REIMAGINE 3 This was a 40-week, randomised, double-blind, placebo-controlled trial evaluating the efficacy and safety of both doses of CagriSema as an add-on to once-daily basal insulin in 274 people (54% male) with type 2 diabetes and a baseline HbA 1c of 53–91 mmol/mol (7.0–10.5%)

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Polyphenols, such as quercetin, catechins, and chlorogenic acid, have been shown to enhance the growth of beneficial microbial taxa, including Akkermansia muciniphila , Bifidobacteria , and Faecalibacterium prausnitzii