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Sirtuins also perform other post-translational reactions such as NAD + -dependent desuccinylation, diacylation, and demalonylation, and are important in regulating metabolism, allowing metabolic plasticity 7

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Glutamine synthesis is a highly active metabolic pathway in astrocytes, and several distinct metabolic features of astrocytes are required to sustain the extensive synthesis and release of glutamine (highlighted in Figure 1)