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This conversion can lower intracellular oxidative stress, provided that the H₂O₂ formed is promptly removed by downstream antioxidant enzymes [47], because H₂O₂, although less reactive than •O 2 – , is still a ROS

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Clinical trials have shown that GDNF does not significantly improve motor symptoms in PD patients and is associated with a higher incidence of serious adverse events (179)