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Peptide sequences of HAI, THR and the respective retro-D-versions. | Download Scientific Diagram

Animal experiments in this study were performed in accordance with Yokohama City University Institutional Animal Care and Use Committee guidelines and with ARRIVE guidelines ( All animal experiments were approved by the Institutional Committee of Laboratory Animal Experimentation (Animal Research Center of Yokohama City University, Yokohama, Japan)

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After obtaining favorable results in the investigator-initiated Phase III trial JETALS, and following consultation with Tokushima University, Eisai submitted a new drug application for the treatment of ALS in Japan in January 2024, leading to its approval in September, 2024 and leading to the launch today