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Pre-treat with antihistamines If you consistently experience injection site reactions despite other prevention strategies, taking a non-drowsy antihistamine (cetirizine 10 mg or loratadine 10 mg) 30 to 60 minutes before injection provides a preventive buffer

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Some FDA scientists have urged against this move, stating there’s not enough human trial data on their safety, efficacy, long-term effects, and possible interactions with other medications