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The Bioavailability of Drugs—The Current State of Knowledge

FIGURE 5 4.7 Mitochondrial dysfunction Mitochondria, the energy factory of eukaryotic cells, produce energy through the metabolism of lipids, steroids, and proteins, which play a key role in maintaining cellular stability by regulating Ca 2+ levels, maintaining ROS levels, and regulating apoptosis (Nunnari and Suomalainen, 2012)

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At present, the management of OA primarily centers around alleviating pain, which entails orally administering non-steroidal anti-inflammatory drugs or intra-articular injections of hyaluronic acid and steroids etc