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The symptoms experienced by the patient may include weakness, pale skin, irregular heartbeat, fatigue, shortness of breath, lightheadedness, pain in the chest, headaches, and even cold hands or feet

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In mouse models of lymphedema, inhibition of 15-LO increased CD4+ T cells and Treg apoptosis, aggravated lymphedema, and further demonstrated the protective role of 15-LO (Zamora et al., 2024)